A TOTAL OF 34 INDIGENOUSLY MANUFACTURED PHARMACEUTICAL ORAL LIQUIDS WERE PURCHASED FROM DIFFERENT POTENT MEDICINE STORES IN OWERRI MAIN MARKET FROM AUGUST TO OCTOBER

33

TABLE OF CONTENTS

Title page

Certification    =     =     =     =     =     =     =     ii

Dedication      =     =     =     =     =     =     =     iii

Acknowledgment = =     =     =     =     =     =     iv

Abstract =     =     =     =     =     =     =     =     V

Table of content =  =     =     =     =     =     =     vi

CHAPTER ONE

1.0 Introduction     =     =     =     =     =     =     1

1.2 Factors important in determining the

rate at which a drug is absorbed from

its site of administration are =     =     =     5

1.3 Effect of microorganisms on drugs =     =     6

1.4 Systemic availability of drug    =     =     =     7

1.5 Raw materials   =     =     =     =     =     =     12

1.6 Water supply = =     =     =     =     =     =     13

1.7 Air     =     =     =     =     =     =     =     =     13

1.8 Equipment =     =     =     =     =     =     =     14

1.9 Personnel =     =     =     =     =     =     =     15

1.10 Containers/packaging materials     =     =     16

CHAPTER TWO

2.0 Literature review      =     =     =     =     =     17

CHAPTER THREE

3.0 Materials and methods     =     =     =     =     22

3.1 Sterilization of materials and

aseptic techniques =     =     =     =     =     23

3.2 Pharmaceutical industry visited       =     =     23

3.3 Collection of samples       =     =     =     =     23

3.4 Preparation of media       =     =     =     =     =     24

3.5 Analysis of the samples   =     =     =     =     24

3.6 Sub culturing of samples =     =     =     =     25

3.7 Isolation of bacterial on selective media  =     26

3.8 Identification of isolates =      =     =     =     =     26

3.9 Method of preparation of media      =     =     27

3.10 Gram’s-staining     =     =     =     =     =     28

3.11 Catalase test   =     =     =     =     =     =     29

3.12 Indole test     =     =     =     =     =     =     29

3.13 Motility test = =     =     =     =     =     =     30

13.14 Methyl red test     =     =     =     =     30

3.15 Voges proskauer test     =     =     =     31

3.16 Sugar fermentation test        =     =     =     32

3.17 Triple sugar iron agar (TSI) 32

3.18 Colonial and cellular characteristics

of organisms isolated in drul4g sample on

different media       =     =     =     =     =     =     33

CHAPTER FOUR

4.0 Discussion and Conclusion      =     =     36

Conclusion      =     =     =     =     =     =     41

Recommendations =     =     =     =     =     43

References      =     =     =     =     =     =     44

Appendix 1     =     =     =     =     =     =     47

Appendix 2     =     =     =     =     =     =     52

 

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