STUDIES ON THE EFFECT OF AQUEOUS EXTRACT OF MILLETTIA ABOENSIS LEAVES ON LOMOTIL – INDUCED CONSTIPATION IN WISTAR ALBINO RATS

ABSTRACT Millettia aboensis leaf is a rich source of reducing sugar, tannins, glycosides and flavonoids and has been reported to have medicinal property as well as some physiological potentials. The leaf also has been used by traditional herbalists for general healing of diseases including ulcer and laxatives. This study evaluated the effect of aqueous extract … Read more

RENAL BIOCHEMICAL CHANGES OF PREGNANCY-INDUCED HYPERTENSION IN PREGNANT WOMEN ATTENDING TERTIARY HOSPITALS IN ENUGU STATE

ABSTRACT Pregnancy induced hypertensive disorders have become very common medical complication in Nigeria with its attendant morbidity and mortality. The morbidity and mortality may be associated with its possible effect on the kidneys which was studied. Results of the electrolyte changes from this study showed that there was non-significant difference (p>0.05) in sodium ion concentration … Read more

PRODUCTION, PARTIAL PURIFICATION AND CHARACTERIZATION OF CELLULASE BY ASPERGILLUS NIGER FROM SUBMERGED FERMENTATION OF GRAPE BAGASSE

ABSTRACT The increase in agricultural practices has necessitated the judicious use of agricultural wastes into value added products. In this study the ability of selected cellulosic substrate to induce cellulase production by Aspergillus niger and the ability of the induced enzyme to hydrolyze the cellulosic substrate were assessed. The enzyme was produced by submerged fermentation … Read more

PRODUCTION OF Aspergillus niger GLUCOAMYLASE USING GUINEA CORN STARCH AMYLOPECTIN AS THE ONLY CARBON SOURCE

ABSTRACT This study was aimed at the production of glucoamylase which can be utilised for starch hydrolysis. A fourteen days experimental study was carried out to determine the day of highest glucoamylase activity. Day five and day twelve of the fourteen days experimental study had the highest glucoamylase activity. The specific activity for the crude … Read more

PRODUCTION AND CHARACTERIZATION OF BIODIESEL FROM LUFFA CYLINDRICA SEED OIL

ABSTRACT Biodiesel was produced from the seed oil of Luffa cylindrica. The oil obtained was transesterified to produce methyl-esters and glycerol. The percentage oil yield of 36.32% was obtained from Luffa cylindrica seed. Biodiesel properties of methyl-esters were determined using American Society for Testing and Materials (ASTM) Standards and compared with that of petrodiesel. The … Read more

PREVALENCE AND SEVERITY OF HYPOGLYCAEMIA AND LACTIC ACIDOSIS IN CHILDREN DIAGNOSED WITH Plasmodium falciparum MALARIA

  ABSTRACT The prevalence and severity of hypoglycaemia and lactic acidosis in Nigerian children diagnosed with Plasmodium falciparum malaria were determined in 100 outpatient children aged 3-144 months (12 years). The children were grouped into 2 categories: 3-59 month old and 60-144 month old. The results obtained indicated that out of the 100 children recruited … Read more

PHYTOCHEMICAL, ANTIOXIDANT AND TOXICOLOGICAL PROPERTIES OF METHANOL EXTRACT OF PHYLLANTHUS AMARUS

ABSTRACT The use of medicinal plants for the treatment of many diseases is associated with folk medicine from different parts of the World. However, information on the toxicology of these plants part used in Nigeria folk medicine is rare. Thus, this work is aimed at revealing a range of phytochemicals in the Phyllanthus amarus plant, … Read more

PHYTOCHEMICAL CONSTITUENTS, FREE RADICAL SCAVENGING PROPERTIES AND ANTIDIABETIC POTENTIALS OF METHANOL EXTRACT OF THE STEM (BARK) OF Alstonia boonei ON ALLOXAN-INDUCED DIABETIC ALBINO RATS

ABSTRACT This study was carried out to investigate the phytochemical constituents of the methanol extract of the stem (bark) of Alstonia boonei (MEAB), in vitro antioxidant activity of the extract and its possible antidiabetic and antioxidant potential using alloxan- induced diabetic rats as model. The qualitative analysis of the extract showed a wide range of … Read more

INTERACTION OF ANTIMALARIAL DRUGS (PYRIMETHAMINE AND SULPHADOXINE) WITH NORMAL AND SICKLE HAEMOGLOBINS: A UV-VISIBLE STUDY

ABSTRACT Crude haemoglobins were extracted from blood samples of identified individuals of normal (AA), sickle trait carrier (AS), and sickle (SS) by employing centrifugation techniques. The crude haemoglobins were dialysed at 4oC for 12hr against 50mM Tris-HCl buffer of pH 7.2. The effects of pyrimethamine and sulphadoxine on the haemoglobins in the presence and absence … Read more

EXTRACTION, PARTIAL PURIFICATION AND CHARACTERIZATION OF CELLULASE FROM Aspergillus fumigatus AND Aspergillus flavus IN SUBMERGED FERMENTATION SYSTEM USING BREADFRUIT HULLS AS CARBON SOURCE

CHAPTER ONE INTRODUCTION   Enzymes are the catalysts of biological processes. Like any other catalyst, an enzyme brings the reaction catalyzed to its equilibrium position more quickly than would occur otherwise. An enzyme cannot bring about a reaction with an unfavourable change in free energy unless that reaction can be coupled to one whose free … Read more

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